Here are some DNA jokes for all of you molecular biology and science nerds out there. Explanations are included for the rest of us. Enjoy!

1Bill Clinton’s DNA

Dear Mr. Starr:

The test on the dress came back inconclusive. Everyone in Arkansas has the same DNA.



Explanation: Monica Lewinsky and Bill Clinton had a secret affair while he was President Of The United States. After an encounter with Clinton, Lewinsky saved a blue dress that had Clinton’s “DNA” on it. Clinton is from Arkansas. Sometimes people joke about people in the south all being related. 

2No Genes

“Sorry mate… no genes.”

Explanation: Many high-end nightclubs don’t admit patrons wearing jeans. Jeans and genes are homonyms.

3DNA Ligase

4DNA Test Results May Vary

Explanation: Many people who have tried DNA testing services like 23andMe and AncestryDNA have gotten surprising results.

5Stop Copying Me


Explanation: A DNA copy is an exact copy. Only biological twins and clones have the same DNA.

6DNA Copy

Pick Up Line: Falling in love with you takes less time than my DNA takes to replicate.

7DNA Evidence

Explanation: DNA testing and evidence have had a dramatic impact on the rate of both current and cold case closures. As a result, criminals now have a much harder time getting away with crimes.

9DNA Contamination

Explanation: One of the biggest challenges for forensics investigators and scientists is avoiding DNA contamination.

11Rearrange The DNA

Pick Up Line: DNA spelled backward is AND, like… me AND you.

12Unzip Your Genes

Pick Up Line: Baby, I wish I were DNA Helicase, so I could unzip your genes.

Explanation: A DNA helicase is an enzyme that can “unzip” a strand of DNA down the middle of the helix.


  • Q: What’s do DNA helicase and perverts have in common?
  • A: They both want to unzip your genes

Explanation: A strand of DNA can be “unzipped” with a DNA helicase enzyme.

14DNA Fat Joke

What did the DNA say to the other DNA? “Do these genes make me look fat?”

Explanation: The words jeans and genes are homonyms.

16DNA Printer

Explanation: The two strips of paper coming out of the printer formed a helix, the same shape of DNA.

17Pasta DNA

Explanation: The spiral shape of this pasta noodle looks similar to a DNA helix.

NERD NOTE: Have you ever wondered: “What does DNA stand for?” DNA is the shorter abbreviation for deoxyribonucleic acid. Your DNA consists of two different nucleic acids. Deoxyribonucleic acid (DNA) is the main acid. The secondary acid is ribonucleic acid (RNA).

DNA Jokes And Pick Up Lines

How were these DNA jokes and pick up lines? Did we miss one of your favorite jokes about DNA? Post a comment below. And if you know any biology teachers, please share this page with them. Most of these are clean biology jokes (sorry Bill Clinton) that the average teacher would appreciate.